Steven F. Ziegler, PhD
Title:
Member and Director, Immunology Program
Email Address:
Background
Dr. Ziegler graduated with honors from the University of Michigan in 1979, and in 1984 received his PhD in molecular biology from UCLA. Following post-doctoral training at the University of Washington, Dr. Ziegler spent five years as a staff scientist at Immunex, followed by three years as the Director of Immunology/Molecular Biology at Darwin Molecular. He joined the Benaroya Research Institute as an Associate Member in 1997. He is currently Director of the Immunology Program at Benaroya Research Institute, and Affiliate Professor in the Immunology Department, University of Washington School of Medicine.
Areas of Research
The projects in Dr. Ziegler’s laboratory are focused on the factors that control normal immune regulation, as well as those that contribute to disease development and progression. The laboratory is currently engaged in two areas of investigation-the genes and cell populations that are involved in controlling autoimmune-type responses, and the role of novel factor (known as TSLP), that is a key initiator of allergic inflammation.
Selected Publications
Yoo, J., Omori, M., Gyarmati, D., Aye, T., Branstatter, D.G., Comeau, M.R., Campbell, D.J., and Ziegler, S.F. (2005). Spontaneous Atopic Dermatitis in Mice Expressing an Inducible Thymic Stromal Lymphopoietin (TSLP) Transgene Specifically in the Skin. J. Exp. Med. 202:541-549.
Zhou, B., Comeau, M.R., De Smedt, T., Liggitt, H.D., Dahl, M.E., Lewis, D.B., Gyarmati, D.,Aye, T., Campbell, D.J., and Ziegler, S.F. (2005). Thymic stromal lymphopoietin as key initiator of allergic airway inflammation in mice. Nature Immunology. 6:1047-1053.
Lopes, J.E.*, Torgerson, T.R.*, Schubert, L.A., Anover, S.D., Ochs, H.D., and Ziegler, S.F. (2006). Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor. J. Immunol. 177:3133-3142.
Lee. H-C., and Ziegler, S.F. (2006). Inducible Expression of the Proallergic Cytokine Thymic Stromal Lymphopoietin in Airway Epithelial Cells Is Controlled by NF?B. Proc Nat Acad Sci (USA). 104:914-919.
Omori, M. and Ziegler, S.F. (2007). Induction of IL-4 Expression in CD4+ T cells by Thymic Stromal Lymphopoietin (TSLP). J. Immunol. 178:1396-1404.
Astrakhan, A., Omori, M*., Nguyen, T*., Becker-Herman, S*., Iseki, M*., Aye, T., Hudkins-Loya, K., Dooley, J., Farr, A.G., Alpers, C.E., Ziegler, S.F., and Rawlings, D.J. (2007). Local Elevations in Thymic Stromal Lymphopoietin Induce Systemic Alterations in B Cell Development. Nat. Immunol. 8:522-531.
Soper, D.M., Kasprowicz, D.J., and Ziegler, S.F. (2007). IL-2Rbeta links IL-2R signaling with Foxp3 expression. Eur J Immunol. 37:1817-26.
Du, J., Huang, C., Zhou, B., and Ziegler, S.F. (2007). Human FOXP3 represses ROR?-mediated transcriptional activation in an isoform-specific, DNA-binding independent manner. J Immunol. In Press.
Zhou, L., Lopes, J.E., Chong, M.M.W., Ivanov, I.I., Min, R., Victora, G.D., Shen, Y.;Du, J., Rubtsov, Y.P., Rudensky, A.Y., Ziegler, S.F., and Littman, D.R. (2008). TGF-?-induced Foxp3 inhibits Th17 cell differentiation by antagonizing ROR?t function. Nature, In Press.